Synthesis and Cytotoxic Activity against K562 and MCF7 Cell Lines of Some N-(5-Arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazoline-2-yl)thio)acetamide Compounds

Table 1

The selective cytotoxicity of compounds 5 and 6a–o against K562 and MCF7 cell lines

No	Compounds	Inhibition of cell growth (%)
		K562	MCF7
1	Doxorubicin	99.1 ± 0.3	96.5 ± 1.3
2	5	7.6 ± 0.6	64.4 ± 6.5
3	6a	23.4 ± 0.6	51.3 ± 0.4
4	6b	13.5 ± 0.7	14.8 ± 3.3
5	6c	4.6 ± 0.1	38.2 ± 1.3
6	6d	34.4 ± 2.7	22.2 ± 0.9
7	6e	36.6 ± 2.0	33.6 ± 2.3
8	6f	22.9 ± 0.6	82.5 ± 5.2
9	6g	8.4 ± 1.1	23.8 ± 0.4
10	6h	33.0 ± 0.7	7.7 ± 0.1
11	6i	15.7 ± 2.3	27.1 ± 0.6
12	6j	52.7 ± 1.0	11.7 ± 0.5
13	6k	38.0 ± 2.1	37.1 ± 2.8
14	6l	22.2 ± 1.3	64.4 ± 2.1
15	6m	18.1 ± 1.2	9.8 ± 0.4
16	6n	23.4 ± 2.0	21.0 ± 1.0
17	6o	3.0 ± 0.1	15.5 ± 0.4