Journal of Chemistry / 2019 / Article / Tab 1

Research Article

Synthesis and Cytotoxic Activity against K562 and MCF7 Cell Lines of Some N-(5-Arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazoline-2-yl)thio)acetamide Compounds

Table 1

The selective cytotoxicity of compounds 5 and 6a–o against K562 and MCF7 cell lines

NoCompoundsInhibition of cell growth (%)
K562MCF7

1Doxorubicin99.1 ± 0.396.5 ± 1.3
257.6 ± 0.664.4 ± 6.5
36a23.4 ± 0.651.3 ± 0.4
46b13.5 ± 0.714.8 ± 3.3
56c4.6 ± 0.138.2 ± 1.3
66d34.4 ± 2.722.2 ± 0.9
76e36.6 ± 2.033.6 ± 2.3
86f22.9 ± 0.682.5 ± 5.2
96g8.4 ± 1.123.8 ± 0.4
106h33.0 ± 0.77.7 ± 0.1
116i15.7 ± 2.327.1 ± 0.6
126j52.7 ± 1.011.7 ± 0.5
136k38.0 ± 2.137.1 ± 2.8
146l22.2 ± 1.364.4 ± 2.1
156m18.1 ± 1.29.8 ± 0.4
166n23.4 ± 2.021.0 ± 1.0
176o3.0 ± 0.115.5 ± 0.4