Parallelism of Chemicostructural Properties between Filgrastim Originator and Three of Its Biosimilar Drugs

Figure 2

MALDI-TOF-MS positive ion spectra of (a) Granulokine® (GRA), (b) Tevagrastim® (TEV), (c) Nivestim™ (NIV), and (d) Zarzio® (ZAR). One microliter of each filgrastim solution, corresponding to 300 ng of protein content, was mixed with 1 μl of CHCA and analyzed with a laser at 337 nm.

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