Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography

Table 4

The experimental values of Log P and the theoretical values of Log P [14] of the investigated compounds.

Compound	Log PTLC		A Log Ps^a	IA Log P^a	C Log P^a	mi Log P^a		x Log P^a
Ketoprofen	2.66	3.12	3.28	2.78	2.76	3.59	3.00	3.22
Naproksen	2.69	3.18	3.29	3.32	2.82	3.38	3.10	2.84
Ibuprofen	3.47	3.97	3.50	3.54	3.68	3.46	3.79	3.64
Flurbiprofen	3.82	4.16	3.57	3.59	3.75	4.05	3.81	3.76

^aValues reported by Pyka et al. [12]; Log P_TLC, the Log P determined in our study with TLC technique; Log P_oct/water, the Log P value determined with the n-octanol/water method.