Design, Antileishmanial Activity, and QSAR Studies of a Series of Piplartine Analogues

<div>Synthesis method: (a) ROH, H2SO4, reflux; (b) Et3N, RBr or RCl, acetone, reflux; (c) SOCl2, reflux (d) DCC, DMAP, CH2Cl2, r.t.; (e) RNH2, (CH3CH2)2NH or pyrrolidine, BOP, Et3N, CH2Cl2, DMF; (f) ROH, CuBr, pyridine, chlorobenzene, BF3·O(Et)2.</div>

Journal of Chemistry

sch1

Scheme 1

Scheme 1: Design, Antileishmanial Activity, and QSAR Studies of a Series of Piplartine Analogues 