An Efficient and Practical Method for the Synthesis of Saxagliptin Intermediate 2-(3-Hydroxy-1-adamantane)-2-oxoacetic Acid and Its Optimization

Table 1

The impact of catalyst on yield.

Catalyst	The feed ratios of the catalyst to raw materials (mol/mol)	The yield of compound IV (%)
Pyridine	1.5	72.1
DMAP	1.5	65.3
Triethylamine	1.5	68.2
DMF	1.5	32.2
—	—	43.0