Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains

Table 1

Mutations in LasR in P. aeruginosa isolates.

Patients	LasR^a	lasR^b	LasR^b
SG1	WT	WT	WT
SG58	WT	WT	WT
AA2	WT	WT	WT
AA12	WT	WT	WT
AA11	MUT	G217A	D73N
TR2	WT	WT	WT
TR1	MUT	C133T	Q45stop
TR66	MUT	C147del	Frameshift
KK1	MUT	T461C	L154P
KK72	MUT	C646T	R216W

^aLasR status evaluated by phenotypic analysis. ^bNumbering is based on the sequence of LasR gene and LasR protein from PAO1.