Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains

Table 2

MIC (μg/ml) of the P. aeruginosa clinical strains.

Clinical strain	LasR status	MIC50 cipro	Diameter inhibitory zone (mm)	Categorization
SG1	WT	0.12	32	S
SG58	WT	0.25	33	S
AA2	WT	1.0	27	I
AA12	WT	0.008	36	S
AA11	MUT	0.5	34	S
TR2	WT	2.0	10	R
TR1	MUT	2.0	13	R
TR66	MUT	1.0	27	I
KK1	MUT	1.0	27	I
KK72	MUT	2.0	11	R

According to the EUCAST Clinical Breakpoint Tables v. 9.0, valid from 2019 to 01-01, the zone diameter breakpoint >26 for susceptible strains (S) and <26 for resistant strains (R).