Oxidative Stress and Apoptosis Contributed to Nonylphenol-Induced Cell Damage in Mouse NCTC Clone 1469 Cells
NP induced oxidative stress in NCTC Clone 1469 cells. (a) Intracellular ROS levels detected in cells. After exposure to NP for 12 h, NCTC Clone 1469 were collected for DCFH-DA staining followed by flow cytometry analysis. (A–G) Flow cytometric plots. (H) Flow cytometric analysis result. (b) Effect of NP on intracellular SOD activity, CAT activity, and MDA content in NCTC Clone 1469. SOD activity, CAT activity, and MDA content are expressed as % of control. (c) NAC weakened NP-induced alteration of SOD activity, CAT activity, and MDA content. Results are presented as mean ± SD with triplicate measurement. , versus the control group; versus 60 μM NP group.