Synthesis, Spectroscopic Characterization, Structural Studies, and In Vitro Antitumor Activities of Pyridine-3-carbaldehyde Thiosemicarbazone Derivatives
Table 3
IC50 (μM) valuesa of the pyridine-3-carbaldehyde thiosemicarbazone derivatives (1–8) against the 3T3 non-tumor cells and the different human tumor cell lines.
Comp.
Non-tumor cells
Tumor cells
3T3b
H460
HuTu80
DU145
MCF-7
M-14
HT-29
5-FU c
<0.47
3.65 ± 0.81
3.68 ± 0.65
7.51 ± 0.98
2.45 ± 0.28
7.51 ± 0.73
4.54 ± 0.86
1
6.12 ± 0.33
10.90 ± 0.42
7.17 ± 0.35
21.35 ± 0.78
6.27 ± 0.24
3.36 ± 0.10
11.25 ± 0.41
2
>455.67
>455.67
>455.67
>455.67
>455.67
>455.67
>455.67
3
>582.26
>582.26
389.22 + 10.42
582.26 ± 13.74
>582.26
>582.26
>582.26
4
60.49 ± 5.90
98.15 ± 4.12
40.00 ± 3.93
66.53 ± 2.46
73.17 ± 4.38
140.07 ± 1.90
232.35 ± 24.35
5
24.69 ± 2.45
52.95 ± 4.29
40.34 ± 3.56
43.04 ± 2.24
78.24 ± 4.92
>395.09
98.77 ± 6.73
6
537.24 ± 44.83
>537.24
215.47 ± 12.83
537.24 ± 14.04
348.36 ± 9.53
>537.24
537.24 ± 15.68
7
168.34 ± 6.36
254.79 ± 10.21
126.23 ± 9.74
183.09 ± 22.54
151.95 ± 9.12
102.08 ± 16.74
134.64 ± 10.51
8
>384.36
>384.36
>384.36
>384.36
>384.36
>384.36
>384.36
aIC50 corresponds to the concentration required to inhibit a 50% of the cell growth when the cells are exposed to the respective compound during 48 h. The values are mean ± standard deviation of two independent experiments. bMouse embryonic fibroblast cells. c5-fluorouracile.
