Research Article
Synthesis of Phthalimide Imine Derivatives as a Potential Anticancer Agent
Table 3
IC50 values and selectivity indices (SI) of cancer cells treated with imines compounds.
| | Sample | HT-29 colon cancer (IC50 ± SEM, µM), SI | MCF-7 Breast cancer (IC50 ± SEM, µM), SI |
| | H1 | (643.7 ± 9.8), 1.24 | NA | | H2 | NA | NA | | H3 | (625.6 ± 34.2), 1.27 | NA | | H4 | NA | NA | | H5 | (544.5 ± 8.6), 1.46 | (585.5 ± 86.6), 1.36 | | H6 | (253.6 ± 45.6), 3.16 | (293.0 ± 40.7), 2.73 | | H7 | (277.6 ± 57.5), 2.88 | NA | | H8 | (666.9 ± 30.7), 1.20 | NA | | H9 | NA | NA | | H10 | (331.6 ± 6.2), 2.41 | NA | | H11 | NA | NA | | H12 | NA | NA | | H13 | NA | NA | | H14 | (466.9 ± 34.2), 1.69 | (325.2 ± 27.2), 2.46 | | H15 | NA | NA | | H16 | NA | NA | | N-Aminophthalimide | NA | NA | | Control drugs | 5-FU drug (80.6 ± 1.36), 2.03 | TMX drug: (20.24 ± 0.19), 1 |
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NA: not applicable (above testing range).
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