Synthesis and Biological Evaluation of Some 1,8-Naphthalimide-Acridinyl Hybrids

Table 1

The IC₅₀ value of the synthesized compounds on different cell lines (μM).

Compounds	HL-60	MCF-7	HepG2	HeLa	SK-OV-3	MT-4	LO2	BEAS-2B	SH-SY5Y
2a	67.03 ± 0.97	78.63 ± 1.78	>100	58.67 ± 1.06	88.74 ± 2.43	46.79 ± 1.96	>100	>100	>100
2b	>100	75.45 ± 3.22	27.32 ± 2.67	17.51 ± 0.34	32.26 ± 1.74	14.66 ± 0.31	>100	>100	22.34 ± 0.98
5b	>100	>100	>100	>100	>100	>100	>100	>100	57.72 ± 2.14
Cisplatin	3.70 ± 0.14	11.32 ± 0.79	5.83 ± 0.14	10.59 ± 1.40	16.02 ± 0.30	0.84 ± 0.01	10.49 ± 0.38	57.66 ± 3.10	24.08 ± 1.23
Camptothecin	12.25 ± 1.06	2.47 ± 0.29	1.32 ± 0.62	10.25 ± 1.08	8.22 ± 0.66	0.55 ± 0.01	0.030 ± 0.002	2.15 ± 0.17	12.11 ± 0.43
Doxorubicin	4.15 ± 0.35	2.13 ± 0.02	3.61 ± 0.21	12.53 ± 1.22	10.45 ± 0.94	0.78 ± 0.02	0.027 ± 0.001	5.16 ± 0.55	30.57 ± 0.98