Image Digitization of Colorimetric Detection of Acephate Based on Its Complexation with Citrate-Capped Gold Nanoparticles

Osman, Mohd Junaedy; Wan Yunus, Wan Md Zin; Ong, Keat Khim; Chieng, Buong Woei; Mohd Kassim, Noor Azilah; Mohd Noor, Siti Aminah; Feizal Knight, Victor; Abd Rashid, Jahwarhar Izuan; Teoh, Chin Chuang

doi:https://doi.org/10.1155/2020/8872048

Journal of Chemistry

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Abstract Introduction Materials and Methods Results and Discussion Conclusions Data Availability Conflicts of Interest Acknowledgments References Copyright Related Articles

Research Article | Open Access

Volume 2020 | Article ID 8872048 | https://doi.org/10.1155/2020/8872048

Image Digitization of Colorimetric Detection of Acephate Based on Its Complexation with Citrate-Capped Gold Nanoparticles

Mohd Junaedy Osman,¹Wan Md Zin Wan Yunus,²Keat Khim Ong,^1,3Buong Woei Chieng,³Noor Azilah Mohd Kassim,^1,3Siti Aminah Mohd Noor,¹Victor Feizal Knight,³Jahwarhar Izuan Abd Rashid,¹and Chin Chuang Teoh⁴

Academic Editor: Vinod Kumar Tiwari

Received07 Sept 2020

Revised06 Nov 2020

Accepted16 Nov 2020

Published30 Nov 2020

Abstract

Acephate (Ac), an organophosphate (OP) insecticide, is very harmful to human and the environment. Conventional techniques of detection are sensitive and selective but relatively time-consuming, expensive, and require trained personnel. This paper describes the use of an image processing technique to digitize the red values (RVs) of the colour image of Ac-capped gold nanoparticles (Ac-Cit-AuNPs) complex captured using a digital microscope to improve the detection accuracy and precision. The formation of the suspension was characterised using laser test, ultraviolet-visible spectrophotometer (UV-Vis), high-resolution transmission electron microscope (HRTEM), and Fourier Transform infrared spectroscope (FTIR). The linear regression analysis revealed that the detection sensitivity improved as the smaller gold nanoparticles were used. For quantitative measurement using image processing, a good linear relationship (R² = 0.9905 and 0.9924) for Cit-HAuNPs and Cit-MAuNPs, respectively, between the concentration of Ac and average red values was obtained in the range of 0–8 mM. The limit of detection (LOD) for Ac was found to be 0.3 mM and 0.4 mM for Cit-MAuNPs and Cit-HAuNPs, respectively.

1. Introduction

Conventional techniques that are commonly used for the detection of organophosphates (OPs) include high-performance liquid chromatography (HPLC) [1], mass spectrometry [2–4], enzyme-linked immunosorbent assay (ELISA) [5], nanoparticle colour complex formation [6], and biosensors based on inhibition of cholinesterase activity [7, 8]. These methods provided a high selectivity of the detection, but they are relatively time-consuming, expensive, and require trained personnel [2, 9, 10]^. Therefore, discovery of a simple, rapid, and less expensive but reliable, sensitive and selective method for the analysis of OPs, especially for onsite detections, is desirable, especially for quick data gathering in OPs poisoning management.

Interaction of OPs and citrate ion-gold nanoparticle- (Cit-AuNP-) based colorimetric assays are very attractive for rapid detection due to the ease of procedures and visualization of results [11, 12]. The colour change of red Cit-AuNPs suspension to steel-purple complex upon aggregation of the particles has been used as the basis of the colorimetric OPs sensing [13].

Acephate (Ac) (O,S-dimethyl acetylphosphoramidothioate), an organophosphate insecticide [14], inhibits acetylcholinesterase enzyme (AChE) [15, 16]. In addition, this compound can be decomposed into methamidophos, which is even more toxic than the original compound [17], thus posing more harm to insects, birds, mammals, and plants. Since Ac is a hydrophilic compound, it is poorly absorbed by soils. Thus, there was high possibility for this compound to become water contaminant [14]. It has been reported that prolonged exposure to Ac led to significant increase of genotoxicity and cardiotoxicity activities [18, 19].

Figure 1 shows the structural formula of Ac. Generally, OPs undergo SN2 nucleophilic substitution at phosphorus centre [20] via two different pathways (addition-elimination and direct-displacement) [20]. Ac was expected to undergo this substitution at P-N bond.

Citrate-capped gold nanoparticles (Cit-AuNPs) are widely used materials in colorimetric detection methods because of the colour stability, excellent biocompatibility, and convenience for surface functionalization. In addition, Cit-AuNPs have high tendency to display a distinct colour change that makes Cit-AuNPs ideal to be applied for sensing application.

Interestingly, Cit-AuNPs were prepared via various approaches that include chemical, sonochemical, and photochemical paths [21]. The simplest chemical route to prepare this material was by reduction of chloroauric acid (HAuCl₄) using reducing agents such as trisodium citrate, block copolymer, organic acids, or amine compounds [22, 23]. This method produces particles with a diameter size of below than 50 nm which was favourable for surface functionalization due to their large surface area. The colour change of Cit-AuNPs was very sensitive to the particle size, capping agent, and aggregation state of Cit-AuNPs [24–26]. Cit-AuNPs was usually prepared via thermal heating in which chloroauric acid is reduced by trisodium citrate. The product was a diamond red suspension. Recently, microwave radiation heating has been found to be an efficient heating technique to produce much finer Cit-AuNPs [27, 28].

In this preliminary study, the sensitivity of the unmodified Cit-AuNPs synthesized via both thermal heating and microwave radiation, for colorimetric detection of Ac, was compared. The detection was based on the colour change produced from the reaction of Ac and Cit-AuNPs that results distinct colour change from diamond red to dark purple for Ac-Cit-AuNPs complex. To improve its accuracy and precision, the colours of the solutions were photographed and digitised using ImageJ software to obtain their red values (RVs).

2. Materials and Methods

2.1. Materials

Chloroauric acid trihydrate (HAuCl₄.3H₂O; >49% Au basis) (Au) and acephate ((C₄H₁₀NO₃PS) (Ac)) of Pestanal analytical grade were purchased from Sigma-Aldrich, USA. Trisodium citrate dihydrate (C₆H₅Na₃O₇.2H₂O) (Na-Cit) was purchased from Merck KGaA, Germany. All other reagents were of analytical grade. All dilutions were carried out using MilliQ water of 18.2 MΩ cm.

2.1.1. Synthesis of Cit-AuNPs via Thermal Heating Technique

Cit-AuNPs were synthesized based on the reported procedure [27, 29] with some modifications. The details of the procedure used is as follows: 100 mL of 0.25 mM of Au solution was heated under reflux with constant stirring of 300 rpm to boil and followed by rapid addition of 2 mL 34 mM Na-Cit. The reaction mixture was then further boiled under the stirring for 20 minutes. The suspensions were then cooled down to room temperature and stored in dark bottle at 5.0 0.5°C. This suspension was labelled as Cit-HAuNPs.

2.1.2. Synthesis of Cit-AuNPs via Microwave Radiation Technique

The same amounts of the reagents used for the heating technique, i.e., 100 mL of 0.25 mM of Au solution and 2 mL of 34 mM Na-Cit were mixed and placed in a microwave oven (Panasonic NN-CS599S output 1000 w Serial number 5G71230007). The mixture was irradiated for 10 min at 300 w. The produced suspension was cooled down to room temperature, stored in dark bottle at 5.0 0.5°C, and labelled as Cit-MAuNPs.

2.1.3. Colorimetric Detection of Ac Using Cit-AuNPs

Typically, triplicate samples of each 900 µL Cit-HAuNPs or 900 µL Cit-MAuNPs were reacted with 100 µL of Ac of different concentrations (1.00 × 10⁻⁵ mM, 1.00 × 10⁻³ mM, 0.40 mM, 1.00 mM, 4.00 mM, or 8.00 mM) in a glass vial. The colours of the top view of Ac-Cit-HAuNPs or Ac-Cit-MAuNPs suspensions produced were photographed using a portable digital microscope. Considering that, for Ac detection, the colour changes from red suspension to dark purple complex, and it is best to refer to the changes in red values (RVs) compared to referring to green and blue colour channel of the digitized images. The RVs of all images were digitized using ImageJ software and processed using a regression. The maximum readings of absorbance of each Ac-Cit-HAuNPs and Ac-Cit-MAuNPs suspension were measured by ultraviolet-visible spectrophotometry. The particle distribution was studied by high resolution transmission electron microscopy. Formation and interaction of bonding between Ac and Cit-AuNPs were studied by Fourier transform infrared spectroscopy.

3. Characterizations

3.1. Laser Test

Laser test was performed using a Logitech laser pointer with wavelength ranged from 640 nm to 660 nm.

3.2. High Resolution Transmission Electron Microscopy (HRTEM)

HRTEM analysis was performed using a JEOL JEM 2100F HRTEM. Samples of Cit-AuNPs were dropped on the viewing grids and left overnight to dry. The HRTEM image of each sample was obtained, and the average diameter of gold particles, size distribution and standard distribution was manually calculated based on the average of 100 gold particles in the TEM images.

3.3. Ultraviolet-Visible (UV-Vis) Spectroscopy

UV-Vis analysis was performed using a Genesys 6 UV-Vis spectrophotometer at a scanning rate of 1 nm/sec from 200 nm to 1000 nm. Absorbance versus wavelength data was recorded for each sample.

3.4. Fourier Transform Infrared (FTIR) Spectroscopy

FTIR analysis was performed using a Perkin Elmer Spectrum 100 equipped with Attenuated Total Reflection (ATR) accessory. The instrument was set at resolution 4.0 cm⁻¹ and scanning rate of 4 cm⁻¹/sec. The background was collected by use of air before each scan.

3.5. Image Processing

Image processing was carried out using ImageJ software (Oracle, USA) to obtain the image RVs of the respective samples.

4. Results and Discussion

4.1. Synthesis of Cit-AuNPs

In this study, Cit-AuNPs were synthesized via chemical reduction of Au³⁺ ions to Au particles using Na-Cit as the reducing agent. Previous study has reported that there are several steps involved in the formation of Cit-AuNPs [30]. The formation of Cit-AuNPs was indicated by the formation of a diamond red suspension [31–33] and confirmed by a laser test whereby surface plasmon resonance (SPR) phenomenon was observed as shown by the appearance of a laser beam through the suspension (Figures 2(a) and 2(b)) [34]. The SPR phenomenon arose from collective oscillation of the conduction band of electron in Cit-AuNPs [35].

(a)

(b)

(c)

Figure 3 shows absorption spectra of the HAuCl₄ solution, Cit-HAuNPs, and Cit-MAuNPs suspension. The strong absorption peak at 210 nm observed for HAuCl₄ aqueous solution spectrum is due to ligand to metal charge transfer (LMCT) of AuCl₄⁻ ions. [36–39] The absorbances of Cit-HAuNPs and Cit-MAuNPs at 526 nm are 0.1052 and 0.0871, resulting from SPR phenomenon [40, 41] of Cit-HAuNPs and Cit-MAuNPs, respectively. The difference of the absorbance of the Cit-HAuNPs and of the Cit-MAuNPs is probably due to dissimilarity of size of the nanoparticles [36, 42, 43].

Figure 4 shows HRTEM images of Cit-HAuNPs and Cit-MAuNPs. The images show that Cit-AuNPs are mostly in spherical shape. A well-defined interparticle boundary for both Cit-HAuNPs and Cit-MAuNPs suggests that the particles are well separated. In addition, the difference in size was clearly observed from the images. The size distribution histograms of the Cit-AuNPs are shown in Figure 5. From the histograms, the measured particle size of both Cit-HAuNPs and Cit-MAuNPs were ranging between 5 to 30 nm and 2 to 18 nm, respectively. The difference in size might be because the uniform reaction temperature achieved throughout the microwave irradiated technique in comparison with that of the thermal heating technique [28, 44, 45].

(a)

(b)

Figure 6(a) presents FTIR spectra of the Cit-HAuNPs suspension and Na-Cit solution. The presence of broad peak at above 3000 cm⁻¹ suggests O-H stretching indicating the presence of water. Peaks at 1585 cm⁻¹ and 1395 cm⁻¹ show the existence of carboxylate asymmetric stretching (COO⁻ As) and carboxylate symmetric stretching (COO⁻ S), respectively. Peaks at 1280 cm⁻¹ and 1075 cm⁻¹ are due to C-O stretching. Meanwhile, peak at 731 cm⁻¹ indicates carboxylate bending (COO⁻ bending). The shifts of the COO⁻ As peak to higher wavenumber and the peak COO⁻ S to the lower wavenumber, compared to those of the Na-Cit, suggest that the binding of Cit-HAuNPs is through unidentate coordination of citrate ions anchoring only one oxygen atom as shown in Figure 6(b) [46].

(a)

(b)

4.2. Colorimetric Detection of Ac

Figure 7 displays the colour images of Ac-Cit-HAuNPs and Ac-Cit-MAuNPs suspensions formed in the presence of different concentrations of Ac. The diamond red colour of the Cit-AuNPs suspensions changed to dark purple as the concentration of Ac increased. Addition of Ac caused the Ac-Cit-AuNPs to have a “red shift” from 527 nm (Cit-AuNPs) to higher wavelength (Ac-Cit-AuNPs complex) as shown by the UV-Vis spectrum, due to particle aggregation of the complex. Figure 8 shows the absorbance intensity at 527 nm decreased as the concentration of Ac increased. This phenomenon was explained by the formation of larger cluster due to aggregation of particles [31, 35]. Furthermore, a new absorbance peak at 650–750 nm which indicated the particle aggregation, both for Ac-Cit-HAuNPs and Ac-Cit-MAuNPs [47], was observed.

(a)

(b)

TEM images (Figure 9) represent aggregation of nanoparticles after detection of Ac for Cit-HAuNPs and Cit-MAuNPs. Initially, nanoparticles were separated due to repulsion from the citrate ion anchored to Au. Ac interacts at the anion through SN2-type mechanism at phosphate centre, thus leading to aggregation of particles in both cases.

(a)

(b)

The proposed chemical equation for reaction of Ac and Cit-AuNPs is as follows:

Figure 10 shows FTIR spectra of Ac solution and Cit-HAuNPs and Ac-Cit-HAuNPs complex. A broad intense peak around 3350 cm⁻¹ in Cit-HAuNPs and Ac-Cit-HAuNPs FTIR spectra belongs to O-H stretching from water which was the solvent used in this experiment. All indicative peaks for Cit-HAuNPs are mentioned earlier. Table 1 represents the functional group, and it quantifies wavenumber for Ac [48, 49]. Ac, with a central phosphorus atom (P), has characteristic phosphoric (P=O), methyl thiol, methyl ether, and amide bonds (Figure 10). P-N bond cleavage in Ac is a multistep addition-elimination pathway, and amide is replaced by unidentate citrate ion in Cit-AuNPs according to SN2-type mechanism [20, 46, 50] in an acidic condition [46] where an unstable intermediate is formed.

Reaction of Ac with Cit-HAuNPs is a nucleophilic substitution. This reaction occurs at phosphorus atom where citrate ion of Cit-HAuNPs replaces the amide and breaks P-N bond in the Ac structure [17]. The FTIR spectrum of Ac-Cit-AuNPs shows disappearance of the peak at around 3200 cm⁻¹ (N-H stretching) and the reduction of the peak intensity around 1230 cm⁻¹ (P=O and C-N stretching) supporting the suggestion that there is a replacement of the amide group by citrate ion of Cit-HAuNPs. In addition, the intensity of COO⁻ stretching peak around 1395 cm⁻¹ is also reduced after the reaction. Reaction of Ac and Cit-HAuNPs hinders the COO⁻ stretching structure, thus reducing the intensity of its FTIR peak [51]. Figure 11 proposed the schematic of nucleophilic substitution mentioned with assumption that all negatively charged citrate ions were completely reacted with Ac.

4.3. Image Processing

Colour change of Cit-AuNPs was associated with the degree of aggregation of Cit-AuNPs. RVs were attained by capturing the image of the Ac-Cit-AuNPs complex and digitizing the red colour of the captured images by ImageJ software. The RVs can effectively represent the degree of aggregation for Ac-Cit-AuNPs complex [52]. As the concentration of Ac was increased, higher degree of aggregation was expected and colour change from red (Cit-AuNPs) to purple (Ac-Cit-AuNPs) was enhanced. Thus, the RVs were reduced. Table 2 shows the average of RVs of Ac-Cit-HAuNPs and Ac-Cit-MAuNPs. The average values were used in developing linear regression model for each type of particles and found to be fitted with the following equations: Y = 138.6–9.875 X for Cit-HAuNPs and Y = 130.7–10.66 X for Cit-MAuNPs (Figure 12), where Y is the average RVs and X is the concentration of Ac. The slopes of the linear equations represent the sensitivity of both Cit-AuNPs to detect Ac [53–56]. The steeper slope of the Cit-MAuNPs regression compared with that of the Cit-HAuNPs indicates the detection based on Cit-MAuNPs is more sensitive. This shows that the detection sensitivity of the Ac detection improves if smaller Cit-AuNPs are used. This is probably due to the fact that finer nanoparticle size offers larger surface area for the interaction [57, 58]. The R² value was higher when the detection of Ac was conducted using Cit-MAuNPs (0.9924) compared with that of the Cit-HAuNPs (0.9905).

(a)

(b)

5. Conclusions

Cit-AuNPs, prepared through either thermal conventional heating or microwave irradiation, were suitable to be used for colorimetric detection of Ac. UV-Vis and FTIR suggested that SN2 nucleophilic substitution of amide with citrate ion induces nanoparticle aggregation for Ac-Cit-AuNPs responsible for the formation of the purple complex. Finer particles of Cit-MAuNPs provide slightly more sensitive detection of Ac as shown a bigger slope of regression equation obtained.

Data Availability

The data used to support the findings of this study are included within the article.

Conflicts of Interest

The authors declare no conflicts of interest.

Acknowledgments

This work was supported by the Ministry of Education Malaysia (UPNM/2018/CHEMDEF/ST01) and Universiti Pertahanan Nasional Malaysia by providing the workplace to conduct the project.

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Copyright © 2020 Mohd Junaedy Osman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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