Research Article

In Vitro and In Silico Cytotoxic and Antibacterial Activities of a Diterpene from Cousinia alata Schrenk

Table 1

Antimicrobial activity of compounds (% inhibition) compared to DMSO.

CompoundS. aureusB. cereusS. enteritidisC. albicans

100 μg ml−1/50 μg ml−1

192.373.639.551.9
228.848.5−16.718.5
328.145.7−3.61.3
47.146.823.40.3
58.522.78.313.2
6442.729.69.8
716.622.526.79.5
Ampicillin (250 μg ml−1)959078
Nystatin (62.5 μg ml−1)98

50 μg ml−1/25 μg ml−1

176.70.7112.742.5
2−1338.7−205.3
310.719.72.6−7.7
4−9.534−9.2−4.4
5−15.77−19−45.54.4
6−9.8720.8−24.34
7−7.9−46−38.83.2

25 μg ml−1/12.5 μg ml−1

110.82.03−29.614.8
2−27.4−43−30−3.2
312.111.31.7−7.2
418.43.2−8.6−3.2
5−41−72−64.80.6
6−342.2−39.30.3
7−24−48−52.510.24