Research Article
In Vitro and In Silico Cytotoxic and Antibacterial Activities of a Diterpene from Cousinia alata Schrenk
Table 1
Antimicrobial activity of compounds (% inhibition) compared to DMSO.
| Compound | S. aureus | B. cereus | S. enteritidis | C. albicans |
| 100 μg ml−1/50 μg ml−1 |
| 1 | 92.3 | 73.6 | 39.5 | 51.9 | 2 | 28.8 | 48.5 | −16.7 | 18.5 | 3 | 28.1 | 45.7 | −3.6 | 1.3 | 4 | 7.1 | 46.8 | 23.4 | 0.3 | 5 | 8.5 | 22.7 | 8.3 | 13.2 | 6 | 4 | 42.7 | 29.6 | 9.8 | 7 | 16.6 | 22.5 | 26.7 | 9.5 | Ampicillin (250 μg ml−1) | 95 | 90 | 78 | — | Nystatin (62.5 μg ml−1) | — | — | — | 98 |
| 50 μg ml−1/25 μg ml−1 |
| 1 | 76.7 | 0.71 | 12.7 | 42.5 | 2 | −13 | 38.7 | −20 | 5.3 | 3 | 10.7 | 19.7 | 2.6 | −7.7 | 4 | −9.5 | 34 | −9.2 | −4.4 | 5 | −15.77 | −19 | −45.5 | 4.4 | 6 | −9.87 | 20.8 | −24.3 | 4 | 7 | −7.9 | −46 | −38.8 | 3.2 |
| 25 μg ml−1/12.5 μg ml−1 |
| 1 | 10.8 | 2.03 | −29.6 | 14.8 | 2 | −27.4 | −43 | −30 | −3.2 | 3 | 12.1 | 11.3 | 1.7 | −7.2 | 4 | 18.4 | 3.2 | −8.6 | −3.2 | 5 | −41 | −72 | −64.8 | 0.6 | 6 | −34 | 2.2 | −39.3 | 0.3 | 7 | −24 | −48 | −52.5 | 10.24 |
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