Designs, Synthesis, Docking Studies, and Biological Evaluation of Novel Berberine Derivatives Targeting Zika Virus

Figure 4

(a) Compound 4d (thick green lines) in the binding site of NS2B-NS3 protease of ZIKA (ribbon representation). (b) Surface model of the best dock pose of compound 4d with NS2B-NS3 protease.

(a)

(b)