Designs, Synthesis, Docking Studies, and Biological Evaluation of Novel Berberine Derivatives Targeting Zika Virus

Table 3

Anti-ZIKV activity of berberines derivatives.

Name	IC50 (μM)^(a)	CC50 (μM)^(b)	SI (μM)^(c)
BBR	15.5 ± 3.1	62.8 ± 4.9	4.1
4a	35.2 ± 7.1	112.5 ± 11.6	3.2
4b	45.1 ± 9.6	122.8 ± 2.1	2.7
4c	5.9 ± 2.2	44 ± 5.2	7.5
4d	5.3 ± 1.9	80.9 ± 5.7	15.3
5a	37.6 ± 3.8	90.2 ± 8.5	2.4
5b	9.8 ± 1.4	25.2 ± 7.5	2.6
5c	116.3 ± 12.3	325.5 ± 3.6	2.8
5d	29.5 ± 2.3	79.7 ± 12.3	2.7
MA	0.13 ± 0.12	>10	>76.9

^(a)IC₅₀: half-maximal inhibitory concentration. ^(b)CC50 values: half-maximal cytotoxicity concentration. ^(c)SI = CC50/EC50: selective index.