Synthesis and Molecular Docking of Some Grossgemin Amino Derivatives as Tubulin Inhibitors Targeting Colchicine Binding Site

<div>(a) 3D structure of compound 4, docked into the colchicine binding site. (b) Mapping surface showing compound 4, occupying the active pocket of colchicine binding site. (c) 2D structure of compound 4, docked into the colchicine binding site. (d) 3D alignment of compound 4 (carbon atoms in turquoise) with the DAMA-colchicine (carbon atoms in green).</div>

Journal of Chemistry

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Figure 9

Figure 9: Synthesis and Molecular Docking of Some Grossgemin Amino Derivatives as Tubulin Inhibitors Targeting Colchicine Binding Site 