|
|
|
| α-MG derivatives | Position of reaction with α-mangostin | Cancer cell line | IC50 (µM) | Ref. |
|
| 11-Hydroxy-1-isomangostin | Cyclization at C-15 and OH of C-1 | HEY cell | >20 | [56] |
| A549 cells | >20 |
|
| 7-O-Demethyl mangostin | Cyclization at C-13 and OH of C-3 | U87 (malignant glioma) | 6.39 | [57] |
| SGC-7901 (gastric cancer) | 8.09 |
| PC-3 (prostate cancer) | 6.21 |
| H460 | 7.84 |
| PC12 | >50 |
|
| β-Mangostin | Methyl group at -O- group of C-3 | DLD-1 cells | 8.1 | [58] |
| γ-Mangostin | OH group at C-7 | DLD-1 cells | 7.1 |
|
| (E)-1-(3,7-Dimethylocta-2,6-dienyl)-3,6,8-trihydroxy-2-methoxy-7-(3-methylbut-2-enyl)-9H-xanthen-9-one (cowanin) | 2-Methylpent-2-ene (2-methyl-2-pentene) at C-19 | MCF7 | 14.8 | [52] |
| DLD-1 | 18.2 |
| 1-((E)-3,7-Dimethylocta-2,6-dienyl)-3,6,8-trihydroxy-7-((E)-4-hydroxy-3-methylbut-2-enyl)-2-methoxy-9H-xanthen-9-one (cowanol) | 2-Methylpent-2-ene (2-methyl-2-pentene) at C-19, and OH group at C-14 | MCF7 | 14.9 |
| DLD-1 | 18.2 |
|
| 1-Hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9-oxo-9H-xanthene-3,6-diyl diacetate (1b) | Acetylation at OH of C-3 and C-6 | HL-60 | 11.92 | [59] |
| SMMC-7721 | 13.56 |
| A-549 | 11.60 |
| MCF-7 | 16.65 |
| SW480 | 16.17 |
| 5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6(2H)-one (2k) | Cyclization at C-12 and OH of C-3 | HL-60 | 13.72 |
| SMMC-7721 | 11.52 |
| A-549 | 11.47 |
| MCF-7 | 16.80 |
| SW480 | 17.35 |
| 4,5-Dibromo-1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one (3e) | Dibromo at C-4 and C-5 | HL-60 | 14.87 |
| SMMC-7721 | 3.98 |
| A-549 | 12.02 |
| MCF-7 | 19.66 |
| SW480 | 21.29 |
|
| Isopropyl mangostin (IPM) | Isopropyl at C-6 | Cervical cancer | 34.84 | [60] |
| Di-O-Methyl mangostin (DMM) | Dimethyl at OH groups of C-3 and C-6 | Cervical cancer | 15.57 |
|
| α-Mangostin | | MCF-7 | 48.47 | This work |
| NCI–H460 | 47.72 |
| HeLa | 60.61 |
| Hep G2 | 65.48 |
| 1-Hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9-oxo-9h-xanthene-3,6-diyl bis(2-bromobenzoate) (4) | 2-Bromobenzoyl chloride at C-3 and C-6 | MCF-7 | 9.99 |
| NCI–H460 | 10.40 |
| HeLa | 8.79 |
| Hep G2 | 10.76 |
|
