An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase

<div>Superimposition of redocked ligands (in yellow) with the bound conformations of the ligands from the X-ray crystal structures (gray). (a) Pyrimethamine with wild-type PfDHFR (3QGT); (b) pyrimethamine with double mutant PfDHFR (1J3J); (c) WR99210 with quadruple mutant PfDHFR (1J3K); (d) teriflunomide with PfDHODH (1TV5).</div>

Journal of Chemistry

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Figure 3: An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase

Figure 3 | An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase 