An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase

Table 1

Protein targets and grid dimensions used in protein-ligand docking.

Protein target	PDB ID	Bound ligand	Grid coordinates and box dimensions
			Center (x, y, z) (Å)	Box size (x, y, z) (Å)
wt-PfDHFR	3QGT	Pyrimethamine	26.354, 5.978, 59.033	25, 25, 25
dm-PfDHFR	1J3J	Pyrimethamine	26.229, 6.033, 60.103	30, 30, 30
qm-PfDHFR	1J3K	WR99210	29.093, 6.592, 59.560	18, 18, 18
PfDHODH	1TV5	Teriflunomide	38.261, 35.079, 36.636	30, 30, 30