It has been increasingly recognized that reactive oxygen species and nitrogen species (ROS/RNS) play an important role in the pathophysiology of diverse diseases and aging. There is growing scientific agreement that antioxidants, particularly the polyphenolic forms, may help lower the incidence of disease, such as certain cancers, cardiovascular and neurodegenerative diseases, and DNA damage, or even have antiaging properties. The quest for healthy aging has led to the use of antioxidants as a means to disrupt age-associated deterioration in physiological function, dysregulated metabolic processes, or prevention of many age-related diseases.

We invite investigators to contribute original research articles as well as review articles about medicinal chemistry of antioxidants, including antioxidants design, synthesis, pharmacological evaluation, and structure-activity relationships. We are particularly interested in articles describing the new antioxidants for their chemical characterization and biological activities for the basic research and clinical application, advances in relationship between chemical structure and function, new insights into safety assessment for antioxidants, and current concepts in the antioxidant network. Potential topics include, but are not limited to:

• Chemical characterization of antioxidants
• Synthesis of antioxidants
• Pharmacological evaluation
• Structure-activity relationships
• The safety assessment for antioxidants
• Antioxidants and Alzheimer’s disease
• Antioxidants and aging properties
• Antioxidants and cancers
• Antioxidants and cardiovascular diseases
• Antioxidants and neurodegenerative diseases
• Antioxidants and DNA damage
• Antioxidants and other conditions

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/jchem/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jchem/medicinal.chemistry/and/ according to the following timetable: