Journal of Chemistry

Advances in Cell-Based Antioxidant Activity Assays

Publishing date
01 Feb 2020
Submission deadline
11 Oct 2019

Lead Editor

1Instituto Politécnico de Bragança, Bragança, Portugal

2University of Belgrade, Belgrade, Serbia

This issue is now closed for submissions.
More articles will be published in the near future.

Advances in Cell-Based Antioxidant Activity Assays

This issue is now closed for submissions.
More articles will be published in the near future.


Significant advances in recent years have brought major improvements in how to assess the antioxidant capacity of compounds and natural extracts, while serious questions about the chemistry, execution, and application of several assays have been raised among the scientific community. In fact, different analytical methods have been used for decades for screening of antioxidants with inadequate consideration of the reaction chemistry or kinetics and without addressing toxicity issues. Additionally, the results obtained by chemical-based methods cannot extrapolate the performance of the target sample in vivo, since the antioxidant action in biological systems occurs under complex physiological conditions. It is therefore necessary to discontinue or improve some of these methods and to implement cell-based assays to accurately assess the biological relevance of the antioxidant effects. The challenge is to standardize the analytical methods that have been developed and to demonstrate their robustness and flexibility and the actual meaning of the results at the in vivo level.

This special issue aims to cover all the relevant aspects of novel and well-established cell-based assays available for measuring the antioxidant activity of compounds and natural extracts, as well as the chemistry behind these methods and models to quantify antioxidant responses. Advantages of cellular antioxidant assays over chemical-based methods (or vice versa) will also be covered. We invite researchers to contribute original research and review articles on recent advances and applications in this field of antioxidant research that is receiving so much attention in the food and pharmaceutical sciences.

Potential topics include but are not limited to the following:

  • Cellular antioxidant activity of synthetic and natural compounds and extracts
  • The chemistry and mechanisms of action of antioxidant compounds
  • Comparisons of cell-based assays with chemical methods for antioxidant activity evaluation
  • Standardization of antioxidant assays and modeling of antioxidant responses
  • Extraction methods for antioxidant measurements in natural, synthetic, and biological samples
Journal of Chemistry
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