SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated Receptor γ Activators: A Perspective

Figure 31

Apo (1PRG) and RGZ (2PRG) bound crystal structures of PPARγ overlaid (RMS backbone atoms = 1.45 Å). H-12 helix in the apo structure takes the open conformation, while in the RGZ bound structure (2PRG) the H-12 helix is in closed state. RMS for H-12 helix backbone atoms is 4.77 Å.