Review Article

SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated Receptor γ Activators: A Perspective

Figure 6

PPARγ-RXRα-DNA cocomplex crystal structure obtained with RGZ and cis-Retinoic acid bound in the active site (PDB code: 3DZY). Proximity of PPARγ LBD with RXRα LBD and PPRE (DNA) is clear. Interaction of C-terminal helices in the major grove of the DNA and Zn finger motif provides clues for graded activation of different genes by different ligands. This figure has been generated using PyMol [18].
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