Derailing the UPS of Protein Turnover in Cancer and other Human Diseases

Figure 2

Domain organization and conservation of the SERTAD protein family. Sequences were analyzed and aligned using BLAST/ClustalW algorithms. The GenBank (NCBI) accession numbers used are as follows: human SERTAD1 NP_037508, human SERTAD2 NP_055570, human SERTAD3 AAH50643, human SERTAD4 CAB81635, human SERTAD5 NP_060425, Drosophila TARA 𝛼/𝛽 AAF43019/AAF43018, and Drosophila CG2865 AAL13703. Putative ubiquitination sites (CUE domains) are identified in SERTAD1 (aa94–104 and aa160–166), SERTAD2 (aa132–136, aa159–163, and aa273–280), and SERTAD5 (aa24–34).