Tetracycline and Glutathione Inhibit Matrix Metalloproteinase Activity: An In Vitro Study Using Culture Supernatants of L929 and Dalton Lymphoma Cell Lines
Figure 2
(a) Gelatin-zymography gel shows the concentration dependent inhibition of MMP2 (culture supernatant of L929) by tetracycline. EDTA is used as positive control to inhibit MMP activity. (b) In the graph, band density obtained in gelatin-zymographic gel after treatment with different concentrations of tetracycline was compared. Lower band density obtained during tetracycline treatment is a clear indication of MMP inhibition. (c) Gelatin-zymography gel shows the concentration dependent inhibition of MMP2 (culture supernatant of Dalton lymphoma cell lines) by tetracycline. (d) MMP2 proteolytic band showed lower band density compared to the control.
