Table of Contents
Journal of Cancer Research
Volume 2013 (2013), Article ID 328134, 5 pages
http://dx.doi.org/10.1155/2013/328134
Research Article

Tetracycline and Glutathione Inhibit Matrix Metalloproteinase Activity: An In Vitro Study Using Culture Supernatants of L929 and Dalton Lymphoma Cell Lines

Department of Biotechnology, University of Calicut, Malappuram District, Kerala 673635, India

Received 8 November 2013; Revised 12 December 2013; Accepted 13 December 2013

Academic Editor: Andrea Vecchione

Copyright © 2013 Gajanan Kendre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Gross and C. M. Lapiere, “Collagenolytic activity in amphibian tissues: a tissue culture assay,” Proceedings of the National Academy of Sciences of the United States of America, vol. 48, no. 6, pp. 1014–1022, 1962. View at Google Scholar
  2. M. R. Acharya, J. Venitz, W. D. Figg, and A. Sparreboom, “Chemically modified tetracyclines as inhibitors of matrix metalloproteinases,” Drug Resistance Updates, vol. 7, no. 3, pp. 195–208, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Björklund and E. Koivunen, “Gelatinase-mediated migration and invasion of cancer cells,” Biochimica et Biophysica Acta, vol. 1755, no. 1, pp. 37–69, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. C. J. Smith, H. Sayles, T. R. Mikuls, and K. Michaud, “Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects,” Arthritis Research & Therapy, vol. 13, article R168, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Itoh, H. Matsuda, M. Tanioka, K. Kuwabara, S. Itohara, and R. Suzuki, “The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis,” Journal of Immunology, vol. 169, no. 5, pp. 2643–2647, 2002. View at Google Scholar · View at Scopus
  6. B. R. Evans, R. A. Mosig, M. Lobl et al., “Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease winchester syndrome,” The American Journal of Human Genetics, vol. 91, no. 3, pp. 572–576, 2012. View at Publisher · View at Google Scholar
  7. E. Seidlitz, Z. Saikali, and G. Singh, “Use of tetracyclines for bone metastases,” in Bone Metastasis, G. Singh and S. Rabbani, Eds., pp. 293–303, Humana Press, New York, NY, USA, 2005. View at Google Scholar
  8. L. M. Prescott, Microbiology, McGraw-Hill, New York, NY, USA, 5th edition, 2002.
  9. Z. Qiu, C. Dillen, J. Hu et al., “Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes,” Immunobiology, vol. 214, no. 9-10, pp. 835–842, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Gendron, D. Grenier, T. Sorsa, and D. Mayrand, “Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine,” Clinical and Diagnostic Laboratory Immunology, vol. 6, no. 3, pp. 437–439, 1999. View at Google Scholar · View at Scopus
  11. A. Vijayalakshmi and V. Girish, “Affordable image analysis using NIH image/imageJ,” Indian Journal of Cancer, vol. 41, no. 1, p. 47, 2004. View at Google Scholar · View at Scopus
  12. C. C. Liang, A. Y. Park, and J. L. Guan, “In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro,” Nature Protocols, vol. 2, no. 2, pp. 329–333, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Li, N. Amizuka, K. Takeuchi et al., “Histochemical evidence of osteoclastic degradation of extracellular matrix in osteolytic metastasis originating from human lung small carcinoma (SBC-5) cells,” Microscopy Research and Technique, vol. 69, no. 2, pp. 73–83, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Kobayashi, “Mechanism of tumor cell-induced extracellular matrix degradation inhibition of cell-surface proteolytic activity might have a therapeutic effect on tumor cell invasion and metastasis,” Nihon Sanka Fujinka Gakkai Zasshi, vol. 48, no. 8, pp. 623–632, 1996. View at Google Scholar · View at Scopus
  15. R. S. Fife and G. W. Sledge Jr., “Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells,” Journal of Laboratory and Clinical Medicine, vol. 125, no. 3, pp. 407–411, 1995. View at Google Scholar · View at Scopus
  16. R. S. Fife, G. W. Sledge Jr., B. J. Roth, and C. Proctor, “Effects of doxycycline on human prostate cancer cells in vitro,” Cancer Letters, vol. 127, no. 1-2, pp. 37–41, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. B. L. Lokeshwar, M. G. Selzer, B. Q. Zhu, N. L. Block, and L. M. Golub, “Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model,” International Journal of Cancer, vol. 98, no. 2, pp. 297–309, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Ahrens, A. E. Koch, R. M. Pope, M. Stein-Picarella, and M. J. Niedbala, “Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis,” Arthritis and Rheumatism, vol. 39, no. 9, pp. 1576–1587, 1996. View at Google Scholar · View at Scopus
  19. A. Jain, L. Sangal, E. Basal, G. P. Kaushal, and S. K. Agarwal, “Anti-inflammatory effects of erythromycin and tetracycline on Propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils,” Dermatology Online Journal, vol. 8, no. 2, p. 2, 2002. View at Google Scholar · View at Scopus
  20. D. Gerard-Monnier and J. Chaudiere, “Metabolism and antioxidant function of glutathione,” Pathologie Biologie, vol. 44, no. 1, pp. 77–85, 1996. View at Google Scholar · View at Scopus
  21. M. Q. Hassan, R. A. Hadi, Z. S. Al-Rawi, V. A. Padron, and S. J. Stohs, “The glutathione defense system in the pathogenesis of rheumatoid arthritis,” Journal of Applied Toxicology, vol. 21, no. 1, pp. 69–73, 2001. View at Publisher · View at Google Scholar
  22. A. Kamanlı, M. Nazıroğlu, N. Aydılek, and C. Hacıevlıyagil, “Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis,” Cell Biochemistry and Function, vol. 22, no. 1, pp. 53–57, 2004. View at Publisher · View at Google Scholar
  23. D. E. Gomez, D. F. Alonso, H. Yoshiji, and U. P. Thorgeirsson, “Tissue inhibitors of metalloproteinases: structure, regulation and biological functions,” European Journal of Cell Biology, vol. 74, no. 2, pp. 111–122, 1997. View at Google Scholar · View at Scopus