Research Article

The Breakage-Fusion-Bridge Cycle Producing MLL Amplification in a Case of Myelodysplastic Syndrome

Figure 3

Representative images of FISH with the Vysis MLL Dual Color, Break Apart Rearrangement Probe. (a) interphase nucleus showing six clear MLL fusion signals. (b) The der(11;15;12) (thick arrow) with multiple MLL signals and a single fusion signal representing the normal chromosome 11. (c) The ring (11) (thick arrow) also with multiple MLL signals. In (b) and (c) the normal chromosome 11 is indicated by a thin arrow.