Table of Contents
Journal of Cancer Research
Volume 2015, Article ID 769849, 8 pages
Research Article

Validation of Microcirculatory Parameters Derived from the Standard Two-Compartment Model with Murine Xenografts Model

1Department of Oncologic Imaging, National Cancer Centre, Singapore 169610
2School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798
3Laboratory of Molecular Endocrinology, National Cancer Centre, Singapore 169610
4Department of Medical Oncology, National Cancer Centre, Singapore 169610
5Department of Pathology, Singapore General Hospital, Singapore 169608
6Department of Nuclear Medicine, Singapore General Hospital, Singapore 169608
7Roche-Singapore Translational Medicine Hub, Singapore 237994

Received 19 June 2014; Revised 23 December 2014; Accepted 24 December 2014

Academic Editor: Takahiro Yamauchi

Copyright © 2015 Septian Hartono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this study was to validate DCE-MRI parameters such as blood flow (), permeability surface area product (PS), fractional intravascular space (), and fractional extracellular extravascular space (), obtained using a standard two-compartment model against other established analysis methods and histological indices. DCE-MRI datasets of 28 mice implanted with various human cancer xenografts were acquired and analyzed. Statistically significant correlations were found between the parameters derived from the standard two-compartment model (, , , and PS) with the histological markers of intravascular and interstitial space and with the corresponding flow and permeability estimates obtained by the initial slope method and Patlak plot, respectively.