Table of Contents
Journal of Crystallography
Volume 2014, Article ID 936174, 5 pages
Research Article

Synthesis, Crystal Structure, and Hirshfeld Surface Analysis of Ciprofloxacin-Salicylic Acid Molecular Salt

Department of Chemistry, BABA Institute of Technology & Sciences, Visakhapatnam 530048, India

Received 27 December 2013; Accepted 21 February 2014; Published 7 April 2014

Academic Editor: Mehmet Akkurt

Copyright © 2014 Ravikumar Nagalapalli and Shankar Yaga Bheem. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the present study, ciprofloxacin-salicylic acid molecular salt has been synthesized and preliminarily characterized by FT-IR spectroscopy. The single crystal X-ray diffraction (SCXRD) reveals the proton transfer from carboxylic acid group of salicylic acid to piperazine moiety in ciprofloxacin confirming the formation of new molecular salt. The molecular packing of the molecular salt is mainly supported by N+–HO, O–HO, C–HF, C–H, and interactions. The 3D Hirshfeld surfaces and the associated 2D fingerprint plots were investigated for intermolecular hydrogen bonding interactions.