Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives

Table 1

Physicochemical properties of ascorbic acid derivatives.

		Ref
ASC-G
Solubility	714 g/L at 19 ± 1°C	*
Surface tension	71 mN/m (0.99 mg/mL)	*
Stability	Half-life at 50°C: >1 year at pH 4, 7, and 9	*
Toxicity	Acute oral toxicity (LD50): 2500 mg/kg (Rat)	*
	Acute dermal toxicity (LD50): >2000 mg/kg (Rat)
ASC-8
Critical micelle concentration	6 × 10^-3 mol/L (pH2)	[1]
Hydrodynamic radius	25.4 Å	[1]
Head group area	57.6 Å^2	[1]
Aggregation number	84	[1]
ASC-P
Solubility	5.6 mg/mL at 25 ± 0.1°C	**
Toxicity	Acute oral toxicity (LD50): 25000 mg/kg (Mouse)	**
	Acute dermal toxicity (LD50): >3000 mg/kg (Guinea pig)
ASC-S
Solubility	Insoluble in water, soluble in ethanol	***
ASC-DP
Solubility	Insoluble in water	****
Stability	Stable in aqueous media at pH 4, 7, and 10	****
	Stable in methanol	****
Safety	Oral administration: up to 1.25 mg/kg body weight daily	*****

*2-O-α-D-glucopyranosyl-L-ascorbic acid, Full Public Report National Industrial Chemicals Notification and Assessment Scheme, file no. STD/1056, 2003.
** http://www.sciencelab.com/xMSDS-Ascorbyl_palmitate-9922973.
*** http://www.fao.org/ag/agn/jecfa-additives/details.html?id=43.
****Unpublished data.
***** http://www.hc-sc.gc.ca/.