An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines

Figure 2

Scheme of the potential interaction of alum with the NALP3 inflammasome. Caspase-1 is activated, which in turn, promotes the activation of proinflammatory cytokines IL-β, IL-18, and IL-33. This process is abrogated by actin polymerization inhibitors, suggesting that activation of NALP3 requires phagocytosis.