Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats
In vivo pharmacodynamics parameters of insulin glargine with or without SBE7-β-CyD (200 mM). (1) Time to nadir blood glucose concentration. (2) Nadir blood glucose concentration. (3) The cumulative percentage of change in serum glucose levels up to 12 h after-administration. (4) Mean residence time in plasma. Each value represents the mean ± S.E.M. of 5-6 experiments. *, compared to insulin glargine.
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