Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats

Table 3

In vivo pharmacodynamics parameters of insulin glargine with or without SBE7-β-CyD (200 mM). (1) Time to nadir blood glucose concentration. (2) Nadir blood glucose concentration. (3) The cumulative percentage of change in serum glucose levels up to 12 h after-administration. (4) Mean residence time in plasma. Each value represents the mean ± S.E.M. of 5-6 experiments. *𝑃<0.05, compared to insulin glargine.

System	Tnadir^(1) (h)	Cnadir^(2) (%)	AUCG^(3)(%⋅h)	MRTG^(4) (h)
Insulin glargine	1.60±0.16	33.14±1.10	544.66±31.73	2.28±0.03
Insulin glargine/SBE7-𝛽-CyD	3.50±0.05^∗	32.05±4.73	612.36±40.84	2.29±0.01