The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier

Table 1

Targeting MAbs for THL and target tissue.

Targeting MAb	Target receptor	Experimental model and target tissue
Murine OX26 [53]	Rat TfR	(a) Rat C6 or RG2 glioma in culture; (b) Rat C6-790 in cultures; (c) In vivo transport via rat BBB and rat brain cells (neuron and glial). Gene delivery
Rat 8D3 [54]	Mouse TfR	In vivo transport via rat BBB and rat brain cells (neuron and glial). Gene delivery
Murine 8314 [60]	Human IR	(a) Human U87 glioma cultures; (b) In vivo transport via primate/human BBB and brain cells (neuron and glial). Gene delivery
8D3 + 8314 [23]	Mouse TfR + human IR	(a) Experimental human brain tumors in scid mice; (b) In vivo transport via mouse BBB and brain primate/human cells (neuron and glial). Gene delivery
Chimeric anti-TfR [55]	Mouse TfR	Gene delivery in mice
Humanized anti-IR [26]	Human IR	Gene delivery in humans