Review Article
The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier
Table 4
Summary of serum chemistry in long-term treatment with THLs.
| | Assay | Units | Saline | mIgG2a-PIL | OX26-PIL |
| | Sodium | mM | 143 ± 1 | 142 ± 1 | 140 ± 1 | | Potassium | mM | 4.4 ± 0.1 | 4.6 ± 0.1 | 4.6 ± 0.2 | | Chloride | mM | 100 ± 1 | 100 ± 1 | 100 ± 1 | |
CO2 | mM | 29 ± 1 | 29 ± 1 | 27 ± 1 | | Glucose | mg/dL | 168 ± 8 | 160 ± 6 | 163 ± 4 | | Creatinine | mg/dL | 0.45 ± 0.03 | 0.40 ± 0.01 | 0.45 ± 0.02 | | Urea nitrogen | mg/dL | 19 ± 1 | 21 ± 2 | 18 ± 1 | | Total protein | g/dL | 5.2 ± 0.1 | 5.3 ± 0.1 | 5.3 ± 0.1 | | Albumin | g/dL | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | | Bilirubin, total | mg/dL | 0.35 ± 0.03 | 0.25 ± 0.05 | 0.33 ± 0.02 | | Alk phos | U/L | 231 ± 27 | 212 ± 25 | 281 ± 11 | | AST (SGOT) | U/L | 65 ± 5 | 59 ± 2 | 74 ± 6 | | ALT (SGPT) | U/L | 54 ± 2 | 52 ± 3 | 59 ± 1 | | Calcium | mg/dL | 9.4 ± 0.1 | 9.5 ± 0.2 | 9.2 ± 0.1 |
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Data are mean ± SE ( rats in each of the three treatment groups). From [49].
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