Tumor Suppressor Gene-Based Nanotherapy: From Test Tube to the Clinic
Figure 1
Detection of melanoma metastasis by fluorescent imaging. Human melanoma MeWo cell line was stably transfected and selected for GFP positive clones. The MeWo-GFP cells () were injected intravenously via tail vein in nude mice. Mice were euthanized after four to five weeks and observed under normal white light and under fluorescent light. Melanoma tumors were detectable under white light in various organs. However, an increased number of GFP-positive tumors (green fluorescence) were observed under fluorescence light in various organs indicating melanoma metastasis. Additionally, tumors not visible under white light were detected by fluorescence.
