The Impact of Dosing Interval in a Novel Tandem Oral Dosing Strategy: Enhancing the Exposure of Low Solubility Drug Candidates in a Preclinical Setting

Table 3

Detailed tandem dose scheme and grouping (𝑛≥3 for each group).

Dose (mg/Kg)	Frequency/total dose	1 hr interval	1.5 hrs interval	2.5 hrs interval
50 mg/Kg	X3 tandem (150 mg/Kg)	Group 1	Group 2	Group 3
100 mg/Kg	X3 tandem (300 mg/Kg)	Group 4	Group 5	Group 6
200 mg/Kg	X3 tandem (600 mg/Kg)	Group 7	Group 8	Group 9