Lipid Nanocapsule-Based Gels for Enhancement of Transdermal Delivery of Ketorolac Tromethamine
Anti-inflammatory activity (Inhibition %) of ketorolac on paw edema induced with Aerosil injection (0.1 mL of 2.5% w/w) in rats (control), after administration of transdermal gels of optimized ketorolac LNC (0.5% and 2%), the vehicle, and the gel containing 0.5 or 2% of free ketorolac. The formulation of the gels of ketorolac LNC contained (1% Carbomer gel base containing 10% oleic acid and 2% ketorolac loaded in optimized LNCs (S20O25W3.5L3.25) prepared by 20% polyethylene glycol hydroxyl stearate, 3.25% lecithin, 25% Labrafac as the oily phase, and cold water as much as 3.5-folds of the total volume of the primary emulsion).
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