Lipid Nanocapsule-Based Gels for Enhancement of Transdermal Delivery of Ketorolac Tromethamine

Table 4

Permeability of ketorolac tromethamine loaded in optimized nano lipid capsules through hairless rat skins from different gel vehicles compared with free drug loaded in gel of O₁₀C₁ (results are mean ± SD).

Composition of gel vehicle	Permeability ×10^6 (cm/sec)	Flux (𝜇g/cm^2sec)	𝐾𝑚
Free drug in O10C1 gel	0.6±0.03	0.0006
O10C1	8.3±0.6	0.009	74.7
O10C0.5	4.2±0.4	0.005	26. 5
P10C1	2.1±0.2	0.002	5.3
O15C1	3.0±0.6	0.003	12.6
P15C1	2.5±0.4	0.003	7.87
P10C0.5	2.6±0.1	0.003	6.68
P15C0.5	1.0±0.1	0.001	0.25
O15C0.5	3.7±0.2	0.004	24.53