A Novel Domperidone Hydrogel: Preparation, Characterization, Pharmacokinetic, and Pharmacodynamic Properties

Table 3

The ink propulsion rate of the small intestine at peak time or 6 h time point after an intragastric given Motilium tablet or domperidone hydrogel to mice at a dose of 5 mg/kg and the average ink propulsion rate of the small intestine after intragastric given physiological saline to mice. Each point represents mean ± S.D. (𝑛=8).

Ink propulsion rate (%)	Average	Peak time	6 h time point
Physiological saline group	41.9 ± 9.9	/	/
Motilium tablet group	/	57.1 ± 11.5*	38.3 ± 13.2
Domperidone hydrogel group	/	71.5 ± 13.3^**∆	58.0 ± 9.1^*∆

* 𝑃<.05, **𝑃<.01 versus physiological saline group.
^∆𝑃<.05 versus tablet group.