Recent Applications of Liposomes in Ophthalmic Drug Delivery

Table 2

Application of liposomes for the delivery of various drug molecules.

Drug	Formulation	Result	Year	Ref
GCV	Liposomes	In vitro transcorneal permeation and in vivo ocular pharmacokinetics was improved	2007	[26]
Ciprofloxacin	Liposomal hydrogel	Fivefold higher transcorneal permeation than the liposomes alone	2010	[27]
Levofloxacin	Liposomes attached to the contact lens	Drug was released following first-order kinetics for more than 6 days and formulation had showed activity against S. aureus.	2007	[28]
Herpes simplex virus antigens	Periocular vaccine	Treated rabbits showed anti-gB immune response and protected against reactivation of HSV infection	2006	[29]
Acetazolamide	Neutral- and surface-charged liposomes	Positively charged liposomes reduced IOP and exhibited prolonged effect than negatively charged liposomes	2007	[30]
Tacrolimus	Liposomes	More than 50 ng/mL vitreous concentration was maintained for 2 weeks and reduced drug related toxicity	2010	[31]
Vasoactive intestinal peptide	Rhodamine-conjugated liposomes	Liposomes were internalized by retinal Müller glial cells, resident macrophages; majority of the liposomes reached the cervical lymph nodes and resulted in slower release and long-term expression inside the eye	2007	[32]
Clodronate	Liposomes	Effectively inhibit infiltration of ED2-positive macrophages	2005	[33]
Plasmid DNA	Cationic liposomes	Significantly increased transfection efficiency of pDNA	2004	[34]
Therapeutic DNA	Cationic lipoplexes	Achieved good vitreous mobility with moderately pegylated cationic lipoplexes with size less than 500 nm	2005	[35]