Journal of Drug Delivery / 2011 / Article / Tab 6

Research Article

Optimization of Liposomal Lipid Composition for a New, Reactive Sulfur Donor, and In Vivo Efficacy Studies on Mice to Antagonize Cyanide Intoxication

Table 6

Therapeutic protection by various CN antidotal combinations. Control: KCN LD50 = 7.8 (4.6–13.1) mg/kg.

Exp no.KCN dose (mg/kg)TreatmentSurvival (%)

115(SL-DTO-TS-Rh)6/6 (100%)
215(SL-DTO-TS) + SN6/6 (100%)
315(SL-DTO-TS-Rh) + SN6/6 (100%)
420(SL-DTO-TS) + SN 4/6 (67%)
520(SL-DTO-TS-Rh)6/6 (100%)
620(SL-DTO-TS) 3/6 (50%)
720(SL-DTO-TS-Rh) + SN6/6 (100%)

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