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Journal of Drug Delivery
Volume 2012 (2012), Article ID 167896, 14 pages
Review Article

Nanomaterials Toxicity and Cell Death Modalities

1Dipartimento di Farmacologia Sperimentale, Facoltà di Scienze Biotecnologiche, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80139 Napoli, Italy
2INSERM U848, IGR, 39 Rue C. Desmoulins, 94805 Villejuif, France

Received 10 September 2012; Accepted 7 November 2012

Academic Editor: Giuseppe De Rosa

Copyright © 2012 Daniela De Stefano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the last decade, the nanotechnology advancement has developed a plethora of novel and intriguing nanomaterial application in many sectors, including research and medicine. However, many risks have been highlighted in their use, particularly related to their unexpected toxicity in vitro and in vivo experimental models. This paper proposes an overview concerning the cell death modalities induced by the major nanomaterials.