Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery

Figure 5

Cryo-electron micrograph of extruded DOTAP: DOPE liposomes complexed to plasmid DNA. Although these liposomes were prepared by the same protocol that produces BIV DOTAP : Chol, these vesicles cannot wrap and encapsulate nucleic acids. The DNA condenses on the surfaces of the liposomes shown.