Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery

Figure 7

Optimized strategy for delivery and gene expression in the target cell. Optimization of many steps is required to achieve targeted delivery, shielding from nonspecific uptake in nontarget organs and tissues, deshielding, fusion with the cell membrane, entry of nucleic acids into the cell and to the nucleus, and production of gene expression of a cDNA cloned in a plasmid.