Table of Contents Author Guidelines Submit a Manuscript
Journal of Drug Delivery
Volume 2012, Article ID 236713, 11 pages
http://dx.doi.org/10.1155/2012/236713
Research Article

Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions

1Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
2Institute of Biochemistry and Biophysics, (IQUIFIB), National Science Research Council (CONICET), Junín 956, 1113 Buenos Aires, Argentina

Received 31 August 2011; Accepted 2 October 2011

Academic Editor: Rassoul Dinarvand

Copyright © 2012 E. Monteagudo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. S. Chawla and M. M. Amiji, “Cellular uptake and concentrations of tamoxifen upon administration in poly(E-caprolactone) nanoparticles,” AAPS PharmSci, vol. 5, no. 1, article E3, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Peer, J. M. Karp, S. Hong, O. C. Farokhzad, R. Margalit, and R. Langer, “Nanocarriers as an emerging platform for cancer therapy,” Nature Nanotechnology, vol. 2, no. 12, pp. 751–760, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Cukierman and D. R. Khan, “The benefits and challenges associated with the use of drug delivery systems in cancer therapy,” Biochemical Pharmacology, vol. 80, no. 5, pp. 762–770, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. J. Lawrence and G. D. Rees, “Microemulsion-based media as novel drug delivery systems,” Advanced Drug Delivery Reviews, vol. 45, no. 1, pp. 89–121, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. R. G. Strickley, “Solubilizing excipients in oral and injectable formulations,” Pharmaceutical Research, vol. 21, no. 2, pp. 201–230, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. J. B. Tagne, S. Kakumanu, D. Ortiz, T. Shea, and R. J. Nicolosi, “A nanoemulsion formulation of tamoxifen increases its efficacy in a breast cancer cell line,” Molecular Pharmaceutics, vol. 5, no. 2, pp. 280–286, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. A. A. Date and M. S. Nagarsenker, “Parenteral microemulsions: an overview,” International Journal of Pharmaceutics, vol. 355, no. 1-2, pp. 19–30, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Gupta and S. P. Moulik, “Biocompatible microemulsions and their prospective uses in drug delivery,” Journal of Pharmaceutical Sciences, vol. 97, no. 1, pp. 22–45, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Gao and J. Singh, “In vitro percutaneous absorption enhancement of a lipophilic drug tamoxifen by terpenes,” Journal of Controlled Release, vol. 51, no. 2-3, pp. 193–199, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Jones, B. J. Daley, B. L. Enderson, J. R. Zhou, and M. D. Karlstad, “Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells,” American Surgeon, vol. 68, no. 6, pp. 575–577, 2002. View at Google Scholar · View at Scopus
  11. R. L. Sutherland, R. E. Hall, and I. W. Taylor, “Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentially growing and plateau-phase cells,” Cancer Research, vol. 43, no. 9, pp. 3998–4006, 1983. View at Google Scholar · View at Scopus
  12. J. G. Hardman, L. E. Limbird, and A. G. Gilman, The Pharmacological Basis of Therapeutics, McGraw-Hill, New York, NY, USA, 10th edition, 2006.
  13. S. C. Shin, J. S. Choi, and X. Li, “Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats,” International Journal of Pharmaceutics, vol. 313, no. 1-2, pp. 144–149, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Tanaka, P. Decuzzi, M. Cristofanilli et al., “Nanotechnology for breast cancer therapy,” Biomedical Microdevices, vol. 11, no. 1, pp. 49–63, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Kakumanu, J. B. Tagne, T. A. Wilson, and R. J. Nicolosi, “A nanoemulsion formulation of dacarbazine reduces tumor size in a xenograft mouse epidermoid carcinoma model compared to dacarbazine suspension,” Nanomedicine, vol. 7, no. 3, pp. 277–283, 2011. View at Publisher · View at Google Scholar
  16. R. Rowe, P. Sheskey, and M. Quinn, Handbook of Pharmaceutical Excipients, Pharmaceutical Press, London, UK, 6th edition, 2010.
  17. C. W. Pouton, “Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system,” European Journal of Pharmaceutical Sciences, vol. 29, no. 3-4, pp. 278–287, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. A. A. Kale and V. B. Patravale, “Development and evaluation of lorazepam microemulsions for parenteral delivery,” AAPS PharmSciTech, vol. 9, no. 3, pp. 966–971, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Spernath, A. Aserin, and N. Garti, “Fully dilutable microemulsions embedded with phospholipids and stabilized by short-chain organic acids and polyols,” Journal of Colloid and Interface Science, vol. 299, no. 2, pp. 900–909, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Gursoy, J. S. Garrigue, A. Razafindratsita, G. Lambert, and S. Benita, “Excipient effects on in vitro cytotoxicity of a novel paclitaxel self-emulsifying drug delivery system,” Journal of Pharmaceutical Sciences, vol. 92, no. 12, pp. 2411–2418, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Nielloud and G. Marti-Mestres, Pharmaceutical Emulsions and Suspensions, Marcel Dekker, New York, NY, USA, 2000.
  22. A. K. Singh, A. Chaurasiya, A. Awasthi et al., “Oral bioavailability enhancement of exemestane from self-microemulsifying drug delivery system (SMEDDS),” AAPS PharmSciTech, vol. 10, no. 3, pp. 906–916, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Palamakula and M. A. Khan, “Evaluation of cytotoxicity of oils used in coenzyme Q10 Self-Emulsifying Drug Delivery Systems (SEDDS),” International Journal of Pharmaceutics, vol. 273, no. 1-2, pp. 63–73, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. C. J. H. Porter, C. W. Pouton, J. F. Cuine, and W. N. Charman, “Enhancing intestinal drug solubilisation using lipid-based delivery systems,” Advanced Drug Delivery Reviews, vol. 60, no. 6, pp. 673–691, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. S. R. Elnaggar, M. A. El-Massik, and O. Y. Abdallah, “Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization,” International Journal of Pharmaceutics, vol. 380, no. 1-2, pp. 133–141, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Sznitowska, E. A. Dabrowska, and S. Janicki, “Solubilizing potential of submicron emulsions and aqueous dispersions of lecithin,” International Journal of Pharmaceutics, vol. 246, no. 1-2, pp. 203–206, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Cavalli, A. Bisazza, R. Bussano et al., “Poly(amidoamine)-cholesterol conjugate nanoparticles obtained by electrospraying as novel tamoxifen delivery system,” Journal of Drug Delivery, vol. 2011, Article ID 587604, 9 pages, 2011. View at Google Scholar
  28. G. R. De Lima, G. Facina, J. Y. Shida et al., “Effects of low dose tamoxifen on normal breast tissue from premenopausal women,” European Journal of Cancer, vol. 39, no. 7, pp. 891–898, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Cavallaro, L. Maniscalco, M. Licciardi, and G. Giammona, “Tamoxifen-loaded polymeric micelles: preparation, physico-chemical characterization and in vitro evaluation studies,” Macromolecular Bioscience, vol. 4, no. 11, pp. 1028–1038, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. F. X. Hu, K. G. Neoh, and E. T. Kang, “Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles,” Biomaterials, vol. 27, no. 33, pp. 5725–5733, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Boonme, K. Krauel, A. Graf, T. Rades, and V. B. Junyaprasert, “Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate/water/Brij 97:1-butanol,” AAPS PharmSciTech, vol. 7, no. 2, article 45, pp. E1–E6, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. W. Zhu, A. Yu, W. Wang, R. Dong, J. Wu, and G. Zhai, “Formulation design of microemulsion for dermal delivery of penciclovir,” International Journal of Pharmaceutics, vol. 360, no. 1-2, pp. 184–190, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Podlogar, M. Gašperlin, M. Tomšič, A. Jamnik, and M. B. Rogač, “Structural characterisation of water-Tween 40/Imwitor 308-isopropyl myristate microemulsions using different experimental methods,” International Journal of Pharmaceutics, vol. 276, no. 1-2, pp. 115–128, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. S. A. Charman, W. N. Charman, M. C. Rogge, T. D. Wilson, F. J. Dutko, and C. W. Pouton, “Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound,” Pharmaceutical Research, vol. 9, no. 1, pp. 87–93, 1992. View at Google Scholar · View at Scopus
  35. B. D. Tarr and S. H. Yalkowsky, “Enhanced intestinal absorption of cyclosporin in rats through the reduction of emulsion droplet size,” Pharmaceutical Research, vol. 6, no. 1, pp. 40–43, 1989. View at Google Scholar · View at Scopus
  36. H. K. Dhiman, A. R. Ray, and A. K. Panda, “Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen,” Biomaterials, vol. 26, no. 9, pp. 979–986, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Zheng, A. Kallio, and P. Härkönen, “Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen,” Endocrinology, vol. 148, no. 6, pp. 2764–2777, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Bañez-Coronel, A. Ramírez de Molina, A. Rodríguez-González et al., “Choline kinase alpha depletion selectively kills tumoral cells,” Current Cancer Drug Targets, vol. 8, no. 8, pp. 709–719, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Sinha Roy, S. Mukhopadhyay, S. Mukherjee, and S. K. Das, “Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats,” Life Sciences, vol. 83, no. 19-20, pp. 661–665, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. N. A. Al Haj, R. Abdullah, S. Ibrahim, and A. Bustamam, “Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques,” American Journal of Pharmacology and Toxicology, vol. 3, no. 3, pp. 219–224, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Shah, D. Bhalodia, and P. Shelat, “Nanoemulsion: a pharmaceutical review,” Systematic Reviews in Pharmacy, vol. 1, no. 1, pp. 24–32, 2010. View at Publisher · View at Google Scholar
  42. M. Licciardi, G. Cavallaro, M. Di Stefano, G. Pitarresi, C. Fiorica, and G. Giammona, “New self-assembling polyaspartylhydrazide copolymer micelles for anticancer drug delivery,” International Journal of Pharmaceutics, vol. 396, no. 1-2, pp. 219–228, 2010. View at Publisher · View at Google Scholar · View at Scopus