Design of an Implantable Device for Ocular Drug Delivery

Table 1

Diffusion coefficient of drugs for the AMD.

Drug	Drug name (type)	Diffusion coefficient (cm^2/s)	Average dosage (nL/min)	Injection amount/periods	References
Antiangiogenic	Macugen (pegaptanib sodium)	3×10^−7	0.2083	3 mg/10 days	Swanson [12]
	Lucentis (ranibizumab)	2.08×10^−7	0.0124	0.5 mg/month	Molokhia et al. [13]
	Intravitrea Avastin (bevacizumab)	1.25×10^−7	0.0289	1.25 mg/month
Synthetic corticosteroid	Fluocinolone	2.3×10^−7	0.0744	15 mg/20 weeks	Li et al. and Jaffe et al. [14, 15]
	Acetonide