Composite Polylactic-Methacrylic Acid Copolymer Nanoparticles for the Delivery of Methotrexate

Table 1

Arrangement of the 3-factor Box-Behnken experimental design for PLA-MAA nanoparticle formulation.

Formulation number	Quantity of PLA (mg)	Quantity of MAA (mg)	Ratio W1: O (mL)
1	2	30.0	1: 5
2	6	17.5	1: 6
3	2	17.5	1: 6
4	4	17.5	1: 5
5	4	30.0	1: 4
6	6	30.0	1: 5
7	2	17.5	1: 4
8	4	17.5	1: 5
9	4	5.0	1: 4
10	6	5.0	1: 5
11	4	5.0	1: 6
12	4	17.5	1: 5
13	4	30.0	1: 6
14	2	5.0	1: 5
15	6	17.5	1: 4