Composite Polylactic-Methacrylic Acid Copolymer Nanoparticles for the Delivery of Methotrexate

Table 3

Response data obtained for the 3-factor Box-Behnken experimental design PLA-MAA nanoparticle formulations.

Formulation number	Size (nm)	PdI value	DEE (%)	Yield (mg)
1	258.2	0.255	5.0	69.65
2	309.8	0.371	6.6	70.45
3	211.1	0.237	5.1	54.60
4	238.2	0.365	4.0	63.80
5	239.5	0.289	8.9	84.00
6	286.3	0.277	8.8	86.20
7	308.4	0.413	7.0	67.50
8	227.3	0.297	4.0	64.20
9	274.8	0.388	5.6	56.85
10	1012.0	0.971	7.3	57.10
11	263.8	0.197	4.9	55.70
12	242.1	0.354	4.2	61.80
13	378.3	0.250	7.6	74.40
14	222.1	0.682	1.5	38.60
15	241.1	0.281	6.0	59.90
Optimized 1	331.0	0.289	12	82.40
Optimized 2	211.0	0.284	98	82.40