Table 1: Pharmacokinetic parameters of total platinum in patients’ sera at the different dose levels.

DosePts A U C 0 A 𝐶 m a x Cl 𝐾 e l 𝑡 1 / 2 𝑉 𝑠 𝑠
mg/m2(n)(h μg/mL)(μg/mL)(L/m2 h) (L/h)(h)(L/m2)

255139.632.48 ± 1.180.180.011460.7915.71
503119.192.87 ± 0.590.420.0001N/AN/A
1005172.893.74 ± 1.180.580.0059117.4698.03
1254256.095.65 ± 2.670.490.008581.5357.42

N/A, not applicable.