Research Article

Application of Collagen-Model Triple-Helical Peptide-Amphiphiles for CD44-Targeted Drug Delivery Systems

Scheme 1

Schematic depiction of targeted liposomal delivery to CD44/CSPG metastatic melanoma cells. The α1(IV)1263–1277 PA (red alkyl tail and green peptide head group) is incorporated into liposomes along with DOX (blue circles). The liposome targets CD44/CSPG (red) on the melanoma cell surface. The liposome-receptor complex is internalized via endocytosis and DOX released. The mechanism of delivery was described previously [23]. This scheme does not explicitly propose how liposomes are trafficked through different intracellular compartments.
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